Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface

Macrophage receptors for Mycobacterium tuberculosis.

Identification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function

Anti-adhesion therapy represents a potentially promising avenue for the treatment and prevention of tuberculosis in a post-antibiotic era. Adhesins are surface-exposed microbial structures or molecules that enable pathogenic organisms to adhere to host surfaces, a fundamental step towards host infection. Although several Mycobacterium tuberculosis adhesins have been identified, it is predicted ...

CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis.

Cell migration and phagocytosis are both important for controlling Mycobacterium tuberculosis infection and are critically dependent on the reorganization of the cytoskeleton. Since CD44 is an adhesion molecule involved in inflammatory responses and is connected to the actin cytoskeleton, we investigated the role of CD44 in both these processes. Macrophage (Mphi) recruitment into M. tuberculosi...

[Macrophage activation syndrome revealing disseminated mycobacterium tuberculosis].

Etant donné que son involution est très rare ainsi son évolution vers la calcification est exceptionnelle, le kyste hydatique cérébral calcifié pose un problème de diagnostic différentiel avec des pathologies tumorales plus courantes [6]. Devant un contexte évocateur, l’apport de l’imagerie par résonance magnétique serait sûrement un plus dans cet approche et seule l’étude histopathologique peu...

Macrophage response to Mycobacterium tuberculosis infection.

The immune response to Mycobacterium tuberculosis (Mtb) infection is the formation of multicellular lesions, or granolomas, in the lung of the individual. However, the structure of the granulomas and the spatial distribution of the immune cells within is not well understood. In this paper we develop a mathematical model investigating the early and initial immune response to Mtb. The model consi...